Epicutis

Dr. Stock spent more than a decade researching and refining a trio of novel ingredients that foster healthier looking skin.

TSC (tetramethylhexadecenyl succinoyl cysteine) is a novel molecule that acts as a super-lipid, dramatically improving skin’s natural barrier function while helping to shield it from a variety of environmental aggressors —including UV rays and pollution.

hyvia® a novel moisturizing agent derived from organic non-GMO chia seed oil, delivers stable potent omega-3 and omega-6 fatty acids—working at the cellular level to help boost hydration, calm inflammation and fight fine lines, wrinkles and other visible signs of skin aging.

DSD (disodium S-phytyl diglycoloylcysteine) is a powerful, proprietary antioxidant that protects against environmental stressors by blocking UV and pollution induced skin damage.

HYVIA™-

Background: Chia seeds have gained importance as it is the highest known plant

source of omega-3 (ω3) polyunsaturated fatty acids. Specifically, chia seeds pos-

sess ω3 α-linolenic acid (ALA) and ω6 linoleic acid (LA), together known as Vitamin

F, which play an important role in maintaining skin function. Protein phosphatase 2A

(PP2A) is a master regulatory protein that plays a critical role in skin barrier function

and its activity is modulated by natural lipids.

Aims: Obtain a chia seed extract (HYVIA™) with significant higher levels of Vitamin F,

determine in vitro PP2A activity and skin hydration markers compared to other com-

mercial chia seed extracts (CCSEs), and evaluate the potential skin hydration benefits

clinically in human subjects.

Methods: A PP2A demethylation assay was utilized to assess PP2A activity. In vitro

studies utilizing normal human epidermal keratinocytes (NHEKs) were treated with

HYVIA™ and gene expression of hydration markers (AQP3, HAS2) were measured by

quantitative PCR (qPCR). A 16-subject clinical trial was performed with 0.1% HYVIA™

formulated in a cream and applied topically to assess its skin moisturizing potential.

Results: We demonstrate here that HYVIA™, ALA, and LA inhibit PP2A demethyla-

tion, boosting PP2A activity, while most other CCSEs do not. Unlike other CCSEs,

HYVIA™ increases keratinocyte hydration factors aquaporin-3 and hyaluronic acid

synthase-2 in vitro. Clinical assessment of 0.1% HYVIA™ cream shows that HYVIA™

improves skin hydration.

Conclusions: HYVIA™ is a novel chia seed extract, enriched for Vitamin F, that modu-

lates PP2A activity and clinically improves skin hydration and barrier function.

BEAUTY DOESN'T HAVE TO BE TOXIC

RE-ENGINEERING SKINCARE

AS WE KNOW IT

WE ARE DONE WITH DANGEROUS BEAUTY.

It’s a fascinating time to be a skincare professional, isn’t it? You and your clients have more skincare choices than ever before, with new brands and their so-called “hero ingredients” making headlines every week. There are vague claims of natural, clinical, clean, green, safe —and so many others. In reality, many of these “heroes” are villains in disguise, and many claims are lacking thorough research. The American skincare industry is largely unregulated, which means you and your clients will have to take these claims at face value. Let’s start with what WE mean when we say we’re CLINICAL, KIND, CLEAN + GREEN.

CLINICAL:

backed by scientific proof + transparency

The Epicutis brand was born in a Princeton research lab, using advanced biotech development methods. Realizing the potential of our technology in the skincare industry, we searched for a brand that met our standards for product transparency, clinical legitimacy, clean formulation and responsible development. Nothing came close—so we created our own brand.

Our research background means that total transparency and data-backed ingredients are part of our DNA. We conduct meticulous analysis on all our individual ingredients and how they combine in our formulations to ensure that when we say “clean,” we really mean it.

KIND:

never tested on animals.

Epicutis products were developed using rigorous scientific testing, along with the help of professional estheticians. They are never, ever, tested on animals.

CLEAN:

simple, safe + fragrance free

We have high standards for what we put on our skin. Epicutis products are EWG Verified™*, Proposition 65-compliant, and approved for use in the European Union, where skincare safety standards are much more stringent than the United States.

Fragrance: the industry’s dark secret. Fragrance is listed as a single ingredient on a product label, but can be packed with dozens of additional hidden ingredients masked as a secret formula. Because we believe in total transparency, all Epicutis products are fragrance free.